Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
A Detour for Prostate Cancer Cell Survival and Growth
Second generation AR antagonists, abiraterone and enzalutamide, induce aberrant HGF/MET and Wnt pathways leading to increased XPO1 expression and ribosomal biosynthesis in double-null prostate cancer (DNPC). However, treatment with XPO1 and ribosomal inhibitors showed an improved antitumor response.
A new low-latitude loess record unveils the rainfall cycle of the East Asian summer monsoon
A low-latitude loess profile from China revealed the dominant ~20,000-year cycle in rainfall change in the core zone of the East Asian summer monsoon, driven by variation in insolation controlled by precession, and precipitation and temperature variation may not follow the same orbital-scale cycles.